2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients.A synovex one grass continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methylnicotinonitrile, that terminates
Acute promyelocytic leukemia is a subtype of acute myeloid leukemia, characterized by the presence of neoplastic promyelocytes, due to the reciprocal balanced translocation between chromosomes 15 and 17.Currently, with the use of agents that act directly on this molecular change, such as all-trans retinoic acid and arsenic trioxide, APL has shifted
Muscle activation (activation time) and the beginning of movement (motor reaction time) can be changed depending on the complexity of the task.The objectives of this study were to compare the time for activation of the paraspinal and the vastus lateralis muscles, and the motor reaction time during the execution of the tasks sit-to-stand (STS) and s